Usefulness of NoneHigh-Density Lipoprotein Cholesterol as a Predictor of Cardiovascular Disease Mortality in Men in 22-Year Follow-Up

Nonehigh-density lipoprotein cholesterol (non-HDL-C) may be equivalent or superior to
low-density lipoprotein cholesterol (LDL-C) for prediction of cardiovascular disease (CVD)
risk. However, studies comparing the predictive values of LDL-C and non-HDL-C for CVD
and total mortality in a long-term follow-up yielded conflicting results. The Cardiovascular
Occupational Risk Factor Determination in Israel Study (CORDIS) is a prospective cohort
study of a young industrial population of workers with a long-term follow-up. The initial
phase of the study was carried out in 1985e1999. Interviews and physical examinations
were conducted, and fasting blood samples, including lipid panels, were undertaken. In
2007, after a 22-year follow-up period, the baseline data were merged with data on all-cause
and CVD mortality obtained from the Israeli National Death Registry. A total of 4,832 men
were included in the analysis with a mean age of 42.1 – 12.1 years. Univariate analysis
indicated a positive association between non-HDL-C and LDL-C levels and an increased
risk for both all-cause and CVD mortality. Multiple regression analysis, following adjustment
for potential confounders, resulted in attenuation of the association of both lipoproteins
with total mortality. The adjusted association between non-HDL-C levels ‡190 mg/dl
and CVD mortality remained significant (hazard ratio 1.80, 95% confidence interval 1.10 to
2.96), but the association of LDL-C with CVD mortality was attenuated (hazard ratio 1.53,
95% confidence interval 0.98 to 2.39). In conclusion, non-HDL-C may be a more potent
predictor of CVD mortality than LDL-C levels.  2017 Elsevier Inc. All rights reserved.
(Am J Cardiol 2017;119:1193e1198)


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